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differential algorithm calculation causes ferritin hematololgy index iron management mcv mds myelodysplasia myelodysplastic normocytic production reticulocyte syndromes
Aplastic Anemia Summary • Definition • Pathophysiology • DDx: AA vs Hypocellular MDS • Expectation •
Aplastic Anemia ... Definition • Pathophysiology ... @ZhuoerXie #Aplastic ... #Anemia #diagnosis ... #oncology #hematololgy
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential Diagnosis ... -100): • Non-hemolytic ... : ACD, Aplastic ... Hemolytic: ... #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
- Differential Diagnosis ... • Marrow Aplasia ... Bleed • Hemolysis ... • Early Iron Deficiency ... Algorithm #Causes #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
deficiencies: Iron deficiency ... marrow failure: Aplastic ... , G6PD deficiency ... Production #Index #hematology ... #diagnosis #calculation
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... , GATA2 deficiency ... #Anemia #oncology ... #hematology #diagnosis
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Anemia - Differential ... Diagnosis Algorithm ... extravascular) hemolysis ... diet, Alcoholism, Tea-toast ... #ferritin #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
• Aplastic Anemia ... or folic acid deficiency ... treatments • Copper deficiency ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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