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differential management workup algorithm causes hemolytic syndrome atlas chronic extravascular intravascular lymphocytic mds monoclonal morphology myelodysplastic rheumatology agglutinin aplastic apml
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... ) (e.g. lupus, CLL ... • Intrinsic RBC ... #hematology #anemia
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
APML, CLL Acute ... - infiltrates (anemia ... Phosphorus CLL ... #Hematology #Oncology ... #Diagnosis
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Burr Cell RBC (Echinocyte ... Microangiopathic Hemolytic ... Bite Cell RBC: G6PD ... #differential #diagnosis ... #hematology #microscopy
Common RBC Inclusions and Associations • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia • Heinz
Common RBC Inclusions ... , Hemolytic anemia ... Thalassemia, Sickle cell ... #Bodies #diagnosis ... #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential Diagnosis ... • Sickle cell ... elliptocytosis - RBC ... anemia • ... Algorithm #Causes #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Diagnosis: • ... Lymphocytosis on CBC ... • Neutropenia, anemia ... #diagnosis #workup ... #oncology #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... Defects: Sickle cell ... anemia, Thalassemias ... #hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... Mean corpuscular (cell ... acute blood loss, hemolysis ... #Algorithm #Diagnosis ... #Workup #Hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
RBC) Morphology ... spherocytosis, Hemolytic ... Schistocytes - Hemolytic ... Morphology #Atlas #key #diagnosis ... #differential #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... Consider sickle cell ... #Anemia #Differential ... #workup #hematology
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