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diagnosis management algorithm differential hepatitis cirrhosis indications lfts transaminitis aclf aih aki albumin alcoholic autoimmune causes chemistry choosingwisely chronic dili
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Circulation Failure Kidney ... Injury (DILI) ... Failure #Cirrhosis #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Liver Injury: ... Liver Injury: ... HBV, HCV, HEV, EBV ... diagnosis #algorithm #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Skin involvement, Kidney ... non-essential drug/HDS treatments ... HBV, HCV, HEV, EBV ... dechallenge • Acute ... #Algorithm #hepatology
Indications for Albumin for Management of Cirrhosis • Large volume paracentesis (>5 liter) - 8g per
) - 8g per liter ... ascites removed • Acute ... kidney injury ( ... Management #Cirrhosis #treatment ... #hepatology
Shotgun Laboratory Testing for Severe Acute Livery Injury https://www.journalofhospitalmedicine.com/jhospmed/article/143598/hospital-medicine/ammonia-levels-and-hepatic-encephalopathy-patients-known #TWDFNR #Testing #Laboratory #LiverInjury #Diagnosis #Workup #Hepatology #EBM #ChoosingWisely
Testing for Severe Acute ... Livery Injury ... Diagnosis #Workup #Hepatology ... #EBM #ChoosingWisely
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 Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
injury < 26 weeks ... cardiac muscle, RBC, Kidney ... Cardiac muscle, Kidneys ... trimester placenta, kidneys ... #differential #Hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... C, A, E, B, D, EBV ... #Injury #Differential ... #algorithm #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... Injury Transaminase ... > 20x normal - Acute ... normal - Infection (EBV ... #Injury #hepatology
Acute Kidney Injury (AKI) - Management Principles Prerenal - Correct hemodynamic derangements: • If low preload →
Acute Kidney Injury ... Treat underlying liver ... → No specific treatment ... #Kidney #Injury ... #treatment #management
Hepatitis B - Treatment Indications Treatment not indicated: • Immune tolerant state - HBe-Ag detectable, high HBV
immunosuppression • Acute ... injury (INR > 2 ... > 3 mg/dL) or acute ... liver failure ... Indications #management #hepatology
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