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diagnosis lupus treatment arteritis druginduced erythematosus gca summary systemic 2ndline cerebritis cns comparison dil hcq hemophagocytic hlh hydroxychloroquine indications levels
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Measurement in SLE ... • Special cases ... #Measurement #SLE ... #rheumatology # ... levels #lupus #management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Diagnosis and Management ... Positive in 60-80% of cases ... Usual therapeutic management ... Erythematosus #Diagnosis #Management ... #Summary #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Induced Lupus vs SLE ... Discontinuation of causal ... Usual therapeutic management ... comparison #table #rheumatology ... #diagnosis #management
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... autoantibodies that will cause ... Erythematosus #SLE ... CNS #neurology #rheumatology ... cerebritis #diagnosis #management
Treatment of giant cell arteritis (GCA) 1st Line Strategy - GC 0.7 mg/kg/day, except for: • Aortitis
MTX or TCZ in case ... TerrierBen #giantcell ... GCA #Treatment #Management ... #Indications #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Autoimmune diseases: SLE ... Drugs, Unknown cause ... 100 mg/m2) : in case ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
identifies 85 to 95% of cases ... them, but urgent rheumatology ... #GiantCell #arteritis ... Symptoms #Diagnosis #Management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Hypocomplementemia • Can cause ... Xerostomia • Dental caries ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
10% of all lupus cases ... is rare in DIL, SCLE-DIL ... Discontinuation of causal ... DrugInduced #Lupus #DIL #rheumatology ... diagnosis #treatment #management
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
hearing loss, nausea ... diseases 30% of cases ... such as: • SLE ... Polychondritis #rheumatology ... #diagnosis #management
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