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ana antinuclear erythematosus sle patterns abnormal activation anca antineutrophil autoantibodies causes classification coagulation druginduced macrophage management mas medications mimickers pharmacology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... (MCTD), Drug-induced ... #Antinuclear #Antibodies ... ANA #patterns #rheumatology ... #diagnosis #differential
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... or Anti-NucIear Antibody ... : Lupus (SLE), Systemic ... ANA #patterns #rheumatology ... #diagnosis #differential
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... ) • Systemic lupus ... Anti-histone (in drug-induced ... SLE) • Systemic ... #diagnosis #rheumatology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... FVIII antibody ... associated with systemic ... #differential # ... hematology #coagulation
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... SLE-Related Auto-Antibodies ... Diagnosis and Lupus ... Mimickers: Drug-induced ... #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... permanent alopecia Differential ... extremities Drug ... activation and/or medications ... #Diagnosis #Rheumatology
Drug Induced Systemic Lupus Erythematosus > 100 drugs have been associated with drug-induced SLE High risk (>5%): •
Drug Induced Systemic ... for 1 year of treatment ... #medications #drugs ... pharmacology #risk #differential ... #diagnosis #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Systemic lupus ... ) • Sepsis • Drug-induced ... Treatment: • Corticosteroids ... #Management #Hematology ... #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... Diagnosis: Systemic ... lupus erythematosus ... C-ANCA) pattern: antibodies ... #diagnosis #rheumatology
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