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diagnosis causes abnormal algorithm aptt arterial atlas bleeding bruising deficiencies dic disseminated embolism extravascular gap globulin hemolysis hemolytic hemostasis hypogammaglobulinemia
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
coagulation (DIC ... G6PD deficiency) ... #Causes #differential ... #diagnosis #hematology ... #anemia
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
, Liver diseases ... Malignant tumors, Acute ... , Liver diseases ... , Disseminated intravascular ... #hematology
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Anticoagulant Medications ... ) • Advanced Liver ... (VIII is most common ... Summary #table #comparison ... #diagnosis #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... , deficiency anemia ... Kawasaki, Nephrotic syndrome ... • Reaction to Medications ... Diagnosis #Algorithm #hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
, Acute blood loss ... : Alcohol use, Liver ... Myelodysplastic syndrome ... morphologic #mcv #differential ... diagnosis #causes #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Hemolytic anemia ... • Liver disease ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Myeloproliferative disease ... • Nephrotic Syndrome ... , Ischemic Liver ... coagulation and ... pathophysiology #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... inhibitors to the common ... Disseminated intravascular ... Causes #diagnosis #differential ... #hematology #coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
von Willebrand syndrome ... • Liver disease ... defects in the common ... disease • Acute ... #Diagnosis #Hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Liver diseases ... autoimmune hemolytic anemia ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology
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