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hematology oncology anemia causes table aflp hellp hemolytic obstetrics pregnancy ttphus workup aplastic cancer chronic extravascular fever gap globulin hemolysis
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Diagnosis Algorithm ... Leukemia, Tumour ... ITP • SLE • CLL ... Diagnosis #Algorithm ... #Causes #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
infiltrates (anemia, thrombocytopenia ... or functional neutropenia ... • Tumor lysis syndrome ... #Hematology #Oncology ... #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• M > F • Affects ... Diagnosis: • ... Cytopenias: • Neutropenia ... , anemia, thrombocytopenia ... #oncology #hematology
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
Bernard-Soulier Syndrome ... structure and cell ... #comparison #table ... #differential # ... diagnosis #hematology
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
Thrombocytopenia ... the critically ill ... AFLP #obstetrics #hematology ... #diagnosis #table ... #comparison
Thrombocytopenia and Pregnancy Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP
Thrombocytopenia ... Pregnancy Three syndromes ... the critically ill ... Obstetrics #OBGyn #Hematology ... #Diagnosis #Comparison
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... microangiopathy: Thrombotic thrombocytopenic ... ) (e.g. lupus, CLL ... Extravascular #Causes #differential ... #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Diagnosis Algorithm ... Consider sickle cell ... Schistocytes, thrombocytopenia ... #Diagnosis #Algorithm ... #workup #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Chronic Myelogenous Leukemia ... Cell Leukemia ... Myeloproliferative Disease • Neutropenia ... blood count with differential ... #diagnosis #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Difficulty breathing • Neutropenia ... - Antithyroid medications ... virus (EBV) • Leukemia ... Anemia #oncology #hematology ... #diagnosis #management
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