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diagnosis hematology differential clinical causes algorithm management hemolytic msk oncology skin lung injection rash rheumatology shoulder thrombocytosis anesthesia cellulitis chronic
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Reactive: • Anemia ... deficiency) • Infection ... Sepsis • Non-infectious ... causes #Platelets #hematology
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Algorithm Signs of anemia ... Hypersplenism, Infection ... #Hemolytic #Anemias ... Diagnosis #Algorithm #hematology
Causes of Hemolytic Anemia - Differential Diagnosis Inherited • Membrane • Internal - Hemoglobin
Causes of Hemolytic Anemia ... Internal - Infectious ... #Hemolytic #Anemia ... Diagnosis #Causes #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
particular degree of anemia ... Index < 2: • Anemia ... (e.g. cancer, infection ... G6PD deficiency), Infections ... Production #Index #hematology
Pediatric Vomiting - Gastrointestinal and Systemic Causes - Differential Diagnosis Algorithm Hepatobiliary: • Acute Hepatitis • Acute
Gastrointestinal - Acute: • Infectious ... Gastrointestinal - Acute: • Infectious ... Urinary Tract Infection ... Hemorrhage • Meningitis ... Ear): • Ear Infection
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
and bacterial infections ... hours • Viral infections ... • Rickettsiae infections ... Pyogenic/focal infection ... viral source Non-Infectious
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... hemolysis, deficiency anemia ... TPO, TPO-RA • Infections ... : Chronic infections ... bacterial and viral infections
Altered Mental Status - Differential Diagnosis • Neurologic: Stroke, Cerebral hypoxia, Cerebral hemorrhage, Seizure, Trauma, TBI,
Electrolyte disturbance, Uremia ... Thyroid disease • Infectious ... Pneumonia, Sepsis, Meningitis ... Recreational drugs, Toxic ingestions
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... Mycoplasma pneumoniae infection ... spherocytosis) • Infections ... differential #diagnosis #hematology ... #anemia
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach to Anemia ... Sideroblastic anemia ... ACD, Aplastic anemia ... Macroangiopathic, Infections ... Differential #Diagnosis #hematology
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