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Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
IBD, Whipple's disease ... • Whipple's disease ... - Whipple's disease ... syndrome - SLE Neurologic ... RA, SLE, Lyme disease
Seronegative Inflammatory Arthritis - Differential Diagnosis
 • Seronegative Rheumatoid Arthritis 
 • Infectious Arthritis: Viral, Bacterial,
• Infectious Arthritis ... Systemic Rheumatic Disease ... Sclerosis, Sjogren's Disease ... Sarcoidosis, Still's Disease ... , Reactive Arthritis
Causes of Severe Aortic Regurgitation - Differential Diagnosis
Acute:
 • Leaflet: Traumatic Rupture, Acute Infective Endocarditis, Acute
Fever, Whipple Disease ... , Crohn Disease ... , Takayasu Arteritis ... , IgG4 Disease, ... Cogan's Disease
3 Stages of Lyme Disease 
Early Lyme Disease 
 - Erythema migrans 
 - Constitutional symptoms
Stages of Lyme Disease ... Early Lyme Disease ... Cutaneous - Neurologic ... - Neurologic ... manifestations - Arthritis
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
Symptoms of Joint Disease ... categories of joint disease ... • Inflammatory arthritis ... trauma (e.g., meniscal ... necrosis, and Paget disease
Causes of Knee Effusions - Differential Diagnosis Framework

Knee Effusion Red Flags:
1. Fever/Chills/Joint pain/Night sweats/Weight loss
	- DDX:
		-
- Systemic disease ... Effusions - Septic Arthritis ... : - Reactive arthritis ... SLE - Behcet Disease ... Ligamentous injuries - Meniscal
Causes of Diffuse Lung Disease. 
Collagen vascular 
 - Scleroderma 
 - Rheumatoid arthritis 
 -
of Diffuse Lung Disease ... - Rheumatoid arthritis ... - Giant cell arteritis ... Metabolic storage disease ... Diffuse #Lung #Disease
Aortitis - Differential Diagnosis Framework
Non-Infectious Aortitis:
 • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Vasculitides: Giant Cell Arteritis ... GCA), Takayasu's arteritis ... ) • Rheumatic Diseases ... : IgG4-Related Disease ... RD), Rheumatoid Arthritis
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
large vessels - Arteritis ... temporalis (giant-cell arteritis ... - Takayasu arteritis ... - Kawasaki disease ... and infectious diseases
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
skin injury) • Neurologic ... myocarditis, coronary arteritis ... SLE, Reactive arthritis ... Ocular melanoma • Arthritis ... SLE, Reactive Arthritis