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rheumatology lupus treatment syndrome disease druginduced erythematosus signs systemic activation adultonset behcet causes coagulation comparison dic disseminated hemophagocytic hlh intravascular
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Constitutional symptoms ... , Arthritis, myalgia ... , SCLE-DIL (terbinafine ... #diagnosis #management
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
erythema nodosum (septal ... Oral aphthae : SLE ... : SLE, Reactive ... #management #signs ... #symptoms #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Systemic Lupus (SLE ... of hip (rare), Arthritis ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Still's Disease Clinical ... Fever, Arthralgia/arthritis ... MAS, Visceral, DIC ... #management #treatment ... #rheumatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
organ damage Clinical ... Subcutaneous dissecting hematoma ... #Coagulation #diagnosis ... causes #treatment #management ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Fever is the main clinical ... erythematosus [SLE ... brucellosis) • Sepsis ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Rheumatoid Arthritis Summary Overview: chronic, inflammatory symmetric polyarthritis involving small joints of hands/feet, knees, shoulders Signs & Symptoms:
Rheumatoid Arthritis ... shoulders Signs & Symptoms ... : CLINICAL DIAGNOSIS ... #diagnosis #management ... #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Differential Diagnosis ... Malignancy (e.g. hematologic ... Induced Lupus: • Symptoms ... Erythematosus #Diagnosis
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
to 1:1 F:M • Clinical ... , Arthritis, myalgia ... , SCLE-DIL (terbinafine ... diagnosis #treatment ... #management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... +++ (Plt, Hb), Hepatic ... Autoimmune diseases: SLE ... #management #treatment
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