18 results
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Diagnosis Framework ... Kasabach-Merritt syndrome ... #Diagnosis #hematology ... #rheumatology #
Vascular Joint Pain - Differential Diagnosis Algorithm 
 - Constant Pain (Ischemia)
 - Acute Onset
 -
- Differential ... Diagnosis Algorithm ... Marfan's Syndrome ... #JointPain #MSK ... #Orthopedics #Causes
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
predispose to other orthopedic ... Avascular necrosis ... • Differentiate ... #diagnosis #causes ... #hematology
Causes of Knee Effusions - Differential Diagnosis Framework

Knee Effusion Red Flags:
1. Fever/Chills/Joint pain/Night sweats/Weight loss
	- DDX:
		-
Knee Effusions - Differential ... Diagnosis Framework ... Ligamentous injuries - Meniscal ... Effusions: - Hematologic ... #diagnosis #msk
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
trauma (e.g., meniscal ... #Joint #Pain #MSK ... #rheumatology # ... approach #workup #differential ... #diagnosis #arthritis
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Hypergammaglobulinemic macular ... (Thrombosis in vascular ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Cathepsin G release → vascular ... initiation • Differential ... Differentiation #Syndrome ... #management #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Diagnosis Framework ... • Nephrotic Syndrome ... pathophysiology #hematology ... #differential # ... diagnosis #vascular
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
and diplopia) • Vascular ... Behcet disease) Differential ... Diagnosis: • Genital ... #diagnosis #management ... signs #symptoms #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Diagnosis: • ANCA-associated ... Non-autoimmune rheumatologic ... Malignancy (e.g. hematologic ... #Rheumatology