188 results
Colchicine Toxicity 
Naturally-occurring plant alkaloid [Autumn Crocus and Glory Lilly]
2-24 hrs 
 • Severe GI distress
Colchicine Toxicity ... Renal failure • Metabolic ... acidosis • ARDS ... #Colchicine #Toxicity ... #Toxicology #Symptoms
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Associated Lactic Acidosis ... use in cellular metabolism ... acidosis including ... LacticAcidosis #Toxicity ... #Toxicology #Diagnosis
 Acute Iron Poisoning

There are five classically described phases of toxicity:
Gastrointestinal phase (~6 hours post-ingestion)
 -
deterioration Shock and metabolic ... acidosis (12-48 ... - Anion gap metabolic ... acidosis with both ... #Toxicology #Diagnosis
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Salicylate Toxicity ... show anion-gap metabolic ... acidosis 4) Presentation ... Acidosis, Respiratory ... #Toxicology #diagnosis
Salicylate Poisoning - Toxicology

Acute toxicity = vomiting, tachypnea, tinnitus, diaphoresis, and lethargy. This may progress to
Salicylate Poisoning - Toxicology ... Acute toxicity ... alkalosis and metabolic ... acidosis. ... #Toxicology #Pharmacology
Stages of Iron Toxicity

Iron overdose can cause an anion gap metabolic acidosis. Severe cases can lead
Stages of Iron Toxicity ... cause an anion gap metabolic ... acidosisMetabolic ... #Stages #Iron #Toxicity ... #Toxicology #Diagnosis
Citrate Anticoagulation Toxicity

Hypernatremia (HyperNa):
 - Citrate solutions may have ↑ sodium content and should be paired
Anticoagulation Toxicity ... think citrate toxicity ... Acidosis: - Citrate ... Metabolic alkalosis ... #toxicology #nephrology
Propofol-Related Infusion Syndrome (PRIS)

Diagnosis is based on a constellation of clinical suspicion and biochemical signs including:
Hyperlactatemia • Metabolic ... acidosis • Rhabdomyolysis ... #Pharmacology #Toxicity ... #Toxicology
Phases of Colchicine Toxicity
 - Early Phase (0-24h) 
 - Multi-organ failure Phase (1-7 days)
of Colchicine Toxicity ... Hemolysis, DIC Metabolic ... : Metabolic acidosis ... #Colchicine #Toxicity ... #Toxicology #Phases
Ethylene Glycol Toxicity

#Pathophysiology #Toxicology #EthyleneGlycol #Metabolism #Fomepizole
Ethylene Glycol Toxicity ... Pathophysiology #Toxicology ... EthyleneGlycol #Metabolism