23 results
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Clinical presentation also ... includes symptoms ... LacticAcidosis #Toxicity ... #Toxicology #Diagnosis ... #Management
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Salicylate Toxicity ... - Diagnosis and ... no respiratory cause ... ingestion/exposure Symptoms ... #Toxicology #diagnosis
 Acute Iron Poisoning

There are five classically described phases of toxicity:
Gastrointestinal phase (~6 hours post-ingestion)
 -
described phases of toxicity ... Abdominal pain, nausea ... post-ingestion) - Symptom ... #Toxicology #Diagnosis ... #Management #Ferrous
Local Anaesthetic Toxicity - Guidelines for Crises in Anaesthesia
Signs of severe toxicity:
 • Sudden alteration in
Guidelines for Crises ... tachyarrhythmias may all ... #Anesthesiology ... Intraoperative #Checklist #Diagnosis ... #Management #Workup
Hypotension - Guidelines for Crises in Anaesthesia

Hypotension is commonly due to unnecessarily deep anaesthesia, the autonomic
Also consider ... Local anaesthetic toxicity ... #Differential #Anesthesiology ... Intraoperative #Checklist #Diagnosis ... #Management #Workup
Histamine Fish Toxicity - Inadequate refrigeration increases enzyme from bacteria on fish 
Clinical 
• Skin flushing,
Histamine Fish Toxicity ... Oral burning, nausea ... palpitations • Symptoms ... eating fish Management ... #Toxicology #Diagnosis
High Central Neuraxial Block - Guidelines for Crises in Anaesthesia
• Can occur with deliberate or accidental
Consider other causes ... Local anaesthetic toxicity ... Neuraxial #Block #Anesthesiology ... Intraoperative #Checklist #Diagnosis ... #Management #Workup
Clozapine Toxicology
Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
Clozapine Toxicology ... effect on negative symptoms ... effects, such as ... Clozapine is known to cause ... #Toxicity #Diagnosis
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Sarcoidosis - Diagnosis ... and Management ... are not caused ... mediators such as ... #Management #Signs
Amiodarone Induced Lung Toxicity Summary

Who?
• 5% of patients
• Dose ≥ 400 mg per day

How?  Possible
gradually with symptoms ... been reported as ... Exclude other causes ... Improvement in symptoms ... #management #Toxicology