9 results
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
anaerobic metabolism Diagnosis ... also includes symptoms ... LacticAcidosis #Toxicity ... #Toxicology #Diagnosis ... #Management
 Acute Iron Poisoning

There are five classically described phases of toxicity:
Gastrointestinal phase (~6 hours post-ingestion)
 -
described phases of toxicity ... Abdominal pain, nausea ... post-ingestion) - Symptom ... #Toxicology #Diagnosis ... #Management #Ferrous
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Salicylate Toxicity ... - Diagnosis and ... no respiratory cause ... ingestion/exposure Symptoms ... #Toxicology #diagnosis
Stages of Iron Toxicity

Iron overdose can cause an anion gap metabolic acidosis. Severe cases can lead
Stages of Iron Toxicity ... can cause an anion ... Recovery from GI symptoms ... #Toxicity #Toxicology ... #Diagnosis #Overdose
Histamine Fish Toxicity - Inadequate refrigeration increases enzyme from bacteria on fish 
Clinical 
• Skin flushing,
Histamine Fish Toxicity ... Oral burning, nausea ... palpitations • Symptoms ... eating fish Management ... #Toxicology #Diagnosis
High Central Neuraxial Block - Guidelines for Crises in Anaesthesia
• Can occur with deliberate or accidental
Consider other causes ... Local anaesthetic toxicity ... Neuraxial #Block #Anesthesiology ... Intraoperative #Checklist #Diagnosis ... #Management #Workup
Amiodarone Induced Lung Toxicity Summary

Who?
• 5% of patients
• Dose ≥ 400 mg per day

How?  Possible
gradually with symptoms ... pneumonitis Diagnosis ... Exclude other causes ... Improvement in symptoms ... #management #Toxicology
Cardiac Arrest - Guidelines for Crises in Anaesthesia

The probable cause is one or more of: something
senior on-call / dial ... Local anaesthetic toxicity ... #Differential #Anesthesiology ... Intraoperative #Checklist #Diagnosis ... #Management #Workup
Intraoperative  Bradycardia - Guidelines for Crises in Anaesthesia
Bradycardia in theatre should not be treated as
Consider known drug causes ... local anaesthetic toxicity ... #Bradycardia #Anesthesiology ... Intraoperative #Checklist #Diagnosis ... #Management #Workup