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Antifungal Echinocandins  - Antibiotics Class Overview

Mechanism: Inhibit glucan synthesis in fungal cell wall by blocking
Micafungin 3. ... #Caspofungin #Micafungin
Antifungal Coverage Activity Antibiogram 

Spectrum of action of systemic antifungal agents. Solid blocks represent species in
itraconazole; MICA = micafungin
Spectrum of activity for systemic antifungal agents
Antifungals: 5FC, flucytosine; AMB, amphotericin B; ANI, anidulafungin; CAS, caspofungin;
itraconazole; MICA, micafungin
Candidemia Workup and Management - IDSA Guidelines
1) Antibiotics
 • Empiric: Echinocandins (e.g. micafungin) for most patients
Echinocandins (e.g. micafungin
Management of Suspected and Confirmed Candida auris 

Isolate patients with suspected C auris 
 • Private
caspofungin, or micafungin
Pulmonary Histoplasmosis
Quick Facts on Histoplasma capsulatum:
 • Dimorphic fungi, in yeast phase within the body
 •
echinocandins (e.g. micafungin
Candida Glabrata
Species of Candida Most Commonly Isolated in Bloodstream Infections
 • Symptomatic mucosal infection is detected
(caspofungin, micafungin
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
(caspofungin, micafungin