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hematology hemophagocytic hlh lymphohistiocytosis treatment alcohol alzheimersdisease apml autoimmune behcet differential differentiation disease etoh fungal geriatrics hemeonc infections infectiousdiseases leukostasis
Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
Clinical Findings Risk ... mutations - Down syndrome ... AlzheimersDisease #Dementia ... pathophysiology #geriatrics #diagnosis ... #signs #symptoms
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Dehydration • Symptoms ... changes, stroke symptoms ... WBC >100k, + lab signs ... #TLS #diagnosis ... #management #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Attempt if high risk ... : >3 symptoms, or ... fluid overload, PCC ... #management #hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
CNS symptoms (headache ... Reactive Arthritis, AS ... #diagnosis #management ... #signs #symptoms ... #rheumatology #
Alcohol Withdrawal Syndrome (AWS) - ICU OnePager Scoring Alcohol Withdrawal Syndrome (AWS): • PAWSS • CIWA-Ar •
Timeline: • Minor ... 3% - High risk ... with normal vital signs ... #AWS #diagnosis ... #treatment #management
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... : HLH signs and ... symptoms can mimic ... #management #treatment ... #hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... papules and Gottron sign ... ) • Shawl sign ... Other Diseases: • PBC ... Myositis #Myopathy #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... Presentation • Common Signs ... and Symptoms: ... : HScore a. ... #Management #Hematology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
• Rheumatologic ... MUCORMYCOSIS • Risk ... Encapsulated yeast • At risk ... transplantation • MCC ... #Management #Infections
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