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Misinterpretation of Urine Toxicology Screen - False Positives and Negatives Dr. Y. Jay Lin @JayLin3455 #Urine #Toxicology #UTox
Misinterpretation ... Screen - False Positives ... #UTox #False #Positives
Misinterpretation of the P-value P-value - Probability for a given statistical model under the null hypothesis
Misinterpretation ... TerrierBen #PValue #Misinterpretation
Medications that Can Cause False Positives on Drug Tests Urine drug screens (UDSs) are simple to use,
Can Cause False Positives ... yielding false-positive ... can cause false positives ... Amphetamine false positives ... may cause false-positive
Important Biostatistics and Epidemiology Equations Sensitivity = TP / (TP + FN) = true positives / disease
TP + FN) = true positives ... disease absent Positive ... TP + FP) = true positives ... / all positives ... all negatives Positive
Summary of Agents Potentially Contributing to False Positives on Urine Drug Screens (UDS) Marijuana Metabolites • dronabinol,
Contributing to False Positives ... Rate of False Positives ... resulting in false-positive ... result in false positives ... enough to prevent positive
Cephalosporins Cephalosporins are bactericidal beta-lactam antibiotics derived from the fungus Acremonlum— they disrupt peptidoglycan formation in
active against gram-positives ... with reduced gram-positive
Vancomycin and Dalbavancin (lipoglycopeptide antibiotics) - Antibiotics Class Overview Mechanism: Glycopeptide - inhibits cell wall synthesis
synthesis in Gram positives ... Spectrum: gram positive ... or proven gram positive ... choice for gram positive
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Aspergillus - Other positives ... in HM • False positives ... Aspergillus - Other Positives ... CGD pts • False Positives ... solutions causing positive
Abnormal (Positive, Upgoing) Babinski Sign on Physical Exam #Abnormal #Positive #Babinski #Sign #PhysicalExam #clinical #video #reflex #pyramidal
Abnormal (Positive ... #Abnormal #Positive
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 Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
mediated - DAT: IgG positive ... , C3 positive or ... IgG negative, C3 positive
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