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diagnosis differential treatment causes anemia classification vasculitis acquired acr2021 activation autoimmune blood bruising cancer cerebritis cns cryofibrinogenemia cryoglobulinemia cryoglobulins dermatology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Differential Diagnosis Algorithm ... Rare • Drugs (e.g ... Coagulation #Bleeding ... #Causes #Hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Differential Diagnosis Algorithm ... 80-100 fL) • Bleeding ... (e.g. ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
IL-1 and IL-6, leading ... purpura to mucosal bleeding ... • Infection (eg ... #Diagnosis #Management ... #Hematology #Rheumatology
Polyarteritis Nodosa (PAN) - Vasculitis Management Algorithm - ACR/VF 2021 Guidelines • Severe Disease → Remission
) - Vasculitis Management ... Algorithm - ACR ... • Non-Severe Disease ... immunosuppressive agent (e.g ... #rheumatology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... Diagnosis and Management ... thrombocythemia), Autoimmune disease ... vonWillebrand #Syndrome ... #treatment #hematology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... screening for disease ... with established disease ... hemophilia type (e.g ... #treatment #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Differential Diagnosis Algorithm ... Increased Requirement (e.g ... Myelodysplastic Syndromes ... • Liver Disease ... #Causes #Hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Cerebrovascular Disease ... Lumbar Puncture, EEG ... CNS #neurology #rheumatology ... cerebritis #diagnosis #management
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
cryoglobulin (CG ... Paradoxical spontaneous bleeding ... Antiphospholipid syndrome ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
immune system, leading ... Hyperviscosity Syndrome ... • Autoimmune diseases ... tissue disorder (e.g ... classification #rheumatology
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