9 results
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... AIH, Wilsons, Pregnancy ... Congenital, Others, Cirrhosis ... Burak @kwburak #LFTs ... #Elevated #Abnormal
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
of Pregnancy (AFLP ... HELLP (Hemolysis, Elevated ... #obstetrics #hematology ... #diagnosis #table ... #comparison
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
HELLP (Hemolysis, Elevated ... Liver tests, Low ... TTPHUS #HELLP #AFLP ... Obstetrics #OBGyn #Hematology ... #Diagnosis #Comparison
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... • Wilson's • Pregnancy ... - AFLP, HELLP ... Infiltrative • Cirrhosis ... • Others #LFTs
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Mild jaundice, Elevated ... of Pregnancy (AFLP ... #hepatitis #comparison ... #differential #diagnosis ... #icp #HELLP #AFLP
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
Primary Biliary Cirrhosis ... pruritus after pregnancy ... Elevated ALP 2. ... Liver biopsy findings ... #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... specificity to elevated ... hepatitis: < 1 • Cirrhosis ... #chemistry #diagnosis ... transaminitis #LFTs
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential Diagnosis ... melanoma, myeloma • Pregnancy ... specificity to elevated ... disease: > 2 • NASH ... hepatitis: < 1 • Cirrhosis
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
/Liver failure ... obstruction • ALP ... or higher • Liver ... cholestasis of pregnancy ... #workup #hepatology