19 results
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Erythematosus - Summary ... Associated with skin ... • Specific for SLE ... #Summary #diagnosis ... #rheumatology #
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... purple, hemorrhagic skin ... Splenomegaly - CTD (SLE ... Associated - SLE ... #hematology #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
) - Diagnosis and ... Management Summary ... Positive in 60-80% of cases ... #Management #Summary ... #rheumatology
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Summary of Coagulation ... RA, SLE), Post-partum ... #Deficiencies #Summary ... #table #comparison ... #diagnosis #hematology
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
decades of life Causes ... Disorientation, vertigo Diagnostic ... Cold #Urticaria #diagnosis ... #rheumatology # ... comparison #table
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
10% of all lupus cases ... Discontinuation of causal ... #comparison #table ... #rheumatology # ... diagnosis #management
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulinemia Summary ... • They can cause ... - Purpura - Skin ... Cryoglobulins Cause ... classification #rheumatology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
Cryofibrinogenemia Summary ... Cryofibrinogenemia Diagnosis ... cryoglobulins • Negative causes ... #rheumatology # ... hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... Autoimmune diseases: SLE ... Drugs, Unknown cause ... management #treatment #summary ... #rheumatology
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
SAPHO Syndrome Summary ... • A clinical diagnosis ... Rule out other causes ... SAPHO #Syndrome #Rheumatology ... #Dermatology