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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Microangiopathies In Systemic ... Erythematosus #SLE #hematology ... #rheumatology # ... differential #diagnosis ... #causes
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
Generalized Differential Diagnosis ... and Primary Causes ... #generalized #dermatology ... #Differential #Diagnosis ... #Algorithm #causes
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... purple, hemorrhagic skin ... #Differential #Diagnosis ... #hematology #rheumatology ... #nonpalpable #dermatology
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
Causes of Splenomegaly ... - Differential Diagnosis ... Inflammatory • Systemic ... #Differential #Diagnosis ... #Hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Causes of Diffuse ... - Differential Diagnosis ... Reactive: - Systemic ... #Algorithm #Causes ... #Hematology #Oncology
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm
Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions
 - Inflammatory
Vesiculobullous Skin ... - Differential Diagnosis ... • Bullous systemic ... Vesiculobullous #SkinRash #dermatology ... #Algorithm #causes
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... - Differential Diagnosis ... Disease Vascular System ... #Algorithm #Causes ... #Hematology
Behcet's Syndrome - Treatment
Ulcers:
 • Treatment: Topical steroids
 • Prevention: Colchicine
 • Azathioprine for refractory disease
Arthritis:
refractory disease Skin ... ophtho referral • Systemic ... Neuro disease: • Systemic ... by case) • Surgery ... #pharmacology #rheumatology
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY

RED FLAGS - In all cases there are specific
markers which
FLAGS - In all cases ... guidelines General - Systemic ... cell disease Rheumatology ... Pathway #Child #Peds ... #Pediatrics #Diagnosis
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... glomerulonephritis (>90%) S - Systemic ... CHAMPS #Mnemonic #diagnosis ... #differential #hematology