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differential signs management sle classification dermatology erythematosus oncology syndrome systemic algorithm arterial arteritis arthritis behcet complications cryofibrinogenemia cryoglobulinemia cryoglobulins disease
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Hypersensitivity vasculitis ... Antiphospholipid-antibody syndrome • Vasculitis ... lesions • Discoid lupus ... #differential #diagnosis ... #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... Sjögrens (15%) Skin ... Butterfly rash, Vasculitis ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Diagnosis of IgA Vasculitis (Henoch-Schönlein Purpura) - French Vasculitis Study Group 1) Suggestive clinical manifestations
Diagnosis of IgA ... especially in the skin ... HenochSchonleinPurpura #HSP #Diagnosis ... #Rheumatology # ... Peds #Pediatrics
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... inflammation Others: • Lupus ... such as systemic lupus ... Presentation - Systemic Symptoms ... #rheumatology #
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... Post-strep GN, Lupus ... Glomerulonephritis #Vasculitis ... #differential #diagnosis ... #algorithm #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... Differential Diagnosis ... Non-autoimmune rheumatologic ... : • Symptoms limited ... #Rheumatology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
inflammation on skin ... Livedo Reticularis, Vasculitis ... Manifestations #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Purpura - Skin ... reticularis & skin ... Labs/Diagnosis: ... (e.g. systemic lupus ... classification #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... Differential Diagnosis ... Presentation: Systemic Symptoms ... • Progressive symptoms ... #Rheumatology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
symptoms by days ... , breast CA - Hematologic ... Leukocytoclastic vasculitis ... ’s syndrome - Lupus ... Sweet #Syndrome #diagnosis
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