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differential rheumatology dermatology management rhabdomyolysis comparison myopathies myopathy neurology treatment vasculitis classification disease inflammatory mnemonic physicalexam rash syndrome table weakness
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... Dermatomyositis ... /full triad at diagnosis ... @AnnKumfer #Autoimmune ... #Myositis #diagnosis
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
Myositis and Myopathies ... Anti-Jo, +Anti-Mi2 Dermatomyositis ... muscle weakness, rash ... Inclusion Body Myositis ... #differential #diagnosis
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Creatine Kinase - Causes ... Inflammatory myopathy: dermatomyositis ... myopathy - Autoimmune ... Inclusion body myositis ... #differential #diagnosis
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
Inflammatory Myopathies Dermatomyositis ... exclusion Necrotizing Autoimmune ... Myositis • Onset ... Inclusion Body Myositis ... #differential #diagnosis
Causes of Rhabdomyolysis - Differential Diagnosis • Drugs & Toxins (Statins, alcohol, cocaine) • Direct Muscle
Causes of Rhabdomyolysis ... - Differential Diagnosis ... Damage (Trauma/crush ... Muscle Disease (myositis ... #Causes
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Causes of Neuromuscular ... Tetanus, Transverse Myelitis ... , Polymyositis/dermatomyositis ... Neuromuscular #Weakness #Causes ... #differential #diagnosis
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
- Differential Diagnosis ... necrotizing myopathy • Autoimmune ... Inclusion body myositis ... Muscle Biopsy: Dermatomyositis ... #Differential #Diagnosis
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
involvement: Intractable nausea ... • Transverse myelitis ... positive NMO only): Myositis ... , Comorbid autoimmune ... Manifestations #diagnosis
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
ANTI-MDA5 DERMATOMYOSITIS ... (blue-purple) rash ... • Erythematous rash ... Men • ~50% of cases ... #dermatology #diagnosis
Erythemas Summarized Erythema ab igne • A dermatosis that results from repeated exposure to heat (fires, heating
malignancies, autoimmune ... infection and autoimmune ... Mycoplasma classic), autoimmune ... sarcoidosis (and other autoimmune ... #differential #diagnosis
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