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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Microangiopathies In Systemic ... Microangiopathies #Systemic ... #rheumatology # ... differential #diagnosis ... #causes
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
SHARP - Lupus Diagnosis ... Anti-phospholipid) M Malar Rash ... D Discoid Rash ... IMDAMNSHARP #sle #systemic ... erythematosus #rheumatology
Rapid Ultrasound in SHock Evaluation
RUSH Protocol:
 • PUMP: LV contractility, RV strain, tamponade
 • TANK: IVC
SHock Evaluation RUSH ... - IVC • M - Morrison's ... jackcfchong #RUSH ... Exam #protocol #diagnosis
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
weakness, less systemic ... can present with rash ... including heliotrope rash ... /full triad at diagnosis ... #rheumatology
RUSH(ed) Exam - POCUS Protocol
Rapid Ultrasound in Shock and Hypotension
1. Parasternal Long Cardiac View
2. Apical Four-Chamber
RUSH(ed) Exam - ... Morison's with Hemothorax ... circumstances #RUSH ... POCUS #Protocol #diagnosis
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features of Systemic ... Photosensitivity, Butterfly rash ... joints Nervous system ... signs #symptoms #diagnosis ... #rheumatology
Infectious Joint Pain - Differential Diagnosis Algorithm 
Polyarticular Join Pain
 • Viral Myalgia
 • Viral Arthritis
- Differential Diagnosis ... & Symmetrical Rash ... (Measles- like rash ... #Algorithm #Orthopedics ... #Causes
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... Manifestations: Malar rash ... Positive in 60-80% of cases ... Management #Summary #rheumatology
Maculopapular Rashes - THE ALGORITHMIC APPROACH 

The term maculopapule is a portmanteau, a combination
of macule and
distribution of the rash ... and systemic toxicity ... and whether the rash ... peripherally distributed rash ... Maculopapular #Rash
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm
Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions
 - Inflammatory
Vesiculobullous Skin Rash ... - Differential Diagnosis ... • Bullous systemic ... #Differential #Diagnosis ... #Algorithm #causes