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Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Erythematosus (SLE ... Myopathy (Also caused ... #MSK #Musculoskeletal ... Complications #pathophysiology ... #signs #symptoms
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
hair follicles -> causes ... Livedo Reticularis, Vasculitis ... Manifestations #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Systemic Lupus (SLE ... , Vasculitis, Purpura ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... Presentation - Systemic Symptoms ... purpura: strong sign ... , and SLE) • Urinalysis ... differential #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
diseases, such as SLE ... purpura: Strong sign ... • Progressive symptoms ... tract, and often causes ... Differential #Diagnosis #Rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
noninflammatory Signs ... constitutional symptoms ... weeks) Can Be Caused ... Differential #Diagnosis #MSK ... #rheumatology #
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... • Bilateral signs ... and/or symptoms ... Disorders: - SLE ... - Sjogren - Vasculitis