421 results
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
Alzheimer's (99% of cases ... Alzheimer's (1% of cases ... precursor protein mutations ... Presenilin 1 and 2 gene mutations ... AlzheimersDisease #Dementia #pathophysiology
Marfan Syndrome - Signs and Symptoms

- Caused by mutations in the fibrillin-1 (FBN1) Gene (chromosome 15)
-
Symptoms - Caused ... by mutations in
Causes of Dilated Cardiomyopathy DCMP - Differential Diagnosis Algorithm
Idiopathic DCMP: Viral, Inflammatory cardiomyopathy, Genetic causes, Unknown
Causes of Dilated ... cardiomyopathy, Genetic causes ... , Unknown causes ... recessive, X-Iinked mutations ... Other secondary causes
Jaundice - Pathophysiology and Causes

- Amy Chung, MD, MSc @AmyChung 

#Jaundice #Pathophysiology #Differential #Unconjugated #Causes #Diagnosis
Jaundice - Pathophysiology ... and Causes - ... #Jaundice #Pathophysiology ... #Unconjugated #Causes
Causes and Pathophysiology of Hypertension

#Causes #Pathophysiology #Hypertension #Primary #Essential #Secondary #Differential

** GrepMed Recommended Text: Guyton and
Causes and Pathophysiology ... Hypertension #Causes ... #Pathophysiology
Causes of Hypercalcemia due to increased Vitamin D levels
 • The BIG 3:
Causes of Hypercalcemia ... elasticum, CYP24A1 mutation ... infantile), SLC34A1 mutation ... Hypercalcemia #VitaminD #causes
Congestive Heart Failure - Causes, Pathophysiology and Differential Diagnosis
 • Dilated Cardiomyopathy 
 • Hypertrophic Cardiomyopathy
Heart Failure - Causes ... , Pathophysiology ... • Other HFpEF Causes ... #HeartFailure #Causes ... #Pathophysiology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Factor V Leiden mutation ... Prothrombin gene mutation ... considered in all cases ... coagulation and other causes ... Venous #Arterial #pathophysiology
Melanoma Pathogenesis

Environmental exposure (UV light) + genetic susceptibility (CDKN2A, CDK4, MC1R, BRAF, p16/ARF genes) → accumulation
accumulation of genetic mutations ... #Pathophysiology
The Pathophysiology of Fat Absorption and Causes of Malabsorption (steatorrhoea)

#Fat #Malabsorption #Pathophysiology #Differential #Steatorrhea #Diarrhea #Diagnosis
The Pathophysiology ... Absorption and Causes ... Malabsorption #Pathophysiology