1520 results
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
of Peripheral Weakness ... No Objective Weakness ... Oculomotor • Myasthenia ... Lambert-Eaton Myasthenic ... Syndrome • Botulism
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
thyroid, Sjogren syndrome ... variable degree of weakness ... Limb- proximal weakness ... syndrome - Miller ... Severe bulbar weakness
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Neuromuscular Weakness ... Guillain-Barre syndrome ... Lambert Eaton Syndrome ... , Myasthenia Gravis ... Neuromuscular #Weakness
Multiple Cranial Neuropathies - High Yield Differential Diagnosis
 • Intrinsic brainstem process
 • Compressive brainstem process
Miller Fisher Syndrome ... important for facial weakness ... : • Myasthenia
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Weakness - Differential ... • Acute stroke syndromes ... Paraneoplastic syndrome ... Lambert-Eaton - Isaacs' syndrome ... Postsynaptic: Myasthenia
Floppy Baby Syndrome
 • Infantile Botulism
 • Acute Flaccid Myelitis
 • Guillain Barre
 • Neonatal Myasthenia
Floppy Baby Syndrome ... Barre • Neonatal Myasthenia ... resistance - Weakness ... #Floppy #Baby #Syndrome
Ptosis - Differential Diagnosis Framework

Ptosis (Greek- to fall) Drooping of the upper eyelid that usually results
Horner’s syndrome ... Myasthenia gravis ... to ptosis and weakness ... • Myasthenia gravis ... Myotonic dystrophy • Myasthenia
Causes of Hypotonic Infant (Floppy Newborn) - Differential Diagnosis Algorithm
Central Nervous System - Decreased LOC, Axial
Decreased LOC, Axial Weakness ... Other Congenital Syndromes ... Profound Peripheral Weakness ... and Transient Myasthenia
Guillain–Barré syndrome (GBS)
(aka: Landry–Guillain–Barré–Strohl syndrome:
	Most common cause of acute flaccid paralysis
	Rapidly progressive ascending paralysis & areflexia
	Autonomic
Guillain–Barré syndrome ... Landry–Guillain–Barré–Strohl syndrome ... diagnosis:  Myasthenia ... Botulism: Descending weakness ... myelitis: Pain, weakness
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
proximal myalgia and weakness ... symmetric muscle weakness ... Guillain-Barré syndrome ... Lambert-Eaton myasthenic ... syndrome (LEMS)