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management rheumatology sle systemic differential activetb classification druginduced latenttb neurology oncology syndrome table tuberculosis activation ana antinuclear arthritis autoantibodies cerebritis
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... 40, F:M 9:1 • Clinical ... • Immunologic Workup ... life-threatening • Treatment
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus ( ... SLE) Clinical ... permeability Diagnosis ... #Erythematosus ... #cerebritis #diagnosis
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
mycobacterial infection (NTM ... Progression: (+) Immune ... rest LTBI (-) Immune ... characteristic features Clinical ... #Diagnosis #Management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Suspect: Clinical ... Differential Diagnosis ... Malignancy (e.g. hematologic ... context of primary immune ... #Diagnosis #Rheumatology
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
mycobacterial infection (NTM ... Progression: (+) Immune ... rest LTBI (-) Immune ... characteristic features Clinical ... #Diagnosis #Management
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... • Immunologic Workup ... Erythematosus ( ... • Immunologic Workup ... #diagnosis #management
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Farr assay) and lupus ... -15% If SLE is clinically ... association with auto-immune ... #erythematosus ... #diagnosis #rheumatology
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
belonging to the Mycobacterium ... Kansasii: • Mimics TB ... Hematologic malignancy ... Diagnosis Of NTM ... Lung Disease: • Clinical
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Immune Reconstitution ... noncompliance • Clinical ... initiation Clinical ... fevers • MAC/NTM ... organizing PNA • Mycobacterium
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus ... erythematosus [ ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology
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