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diagnosis management differential oncology causes algorithm aplastic chronic classification comparison druginduced hemeonc hemolytic hodgkins lymphocytic lymphoma mds myelodysplastic pathophysiology sle
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... ALL Symptoms: ... - infiltrates (anemia ... ) CLL Symptoms: ... #Hematology #Oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
(CLL) - Summary ... of anemia or thrombocytopenia ... marrow failure with anemia ... uw_IMresidency #CLL ... #oncology #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Leukemia, Tumour ... methotrexate) • Drugs Autoimmune ... ITP • SLE • CLL ... Algorithm #Causes #Hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Cancer: • Leukemia ... Inflammatory and Autoimmune ... Diseases: • Systemic lupus ... Differential #Diagnosis #Hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Script Signs and symptoms ... Treatment: • Consider ... stem cell transplant ... to MDS or acute leukemia ... #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... • Neutropenia, anemia ... microglobulin Treatment ... leukemia #CLL ... workup #oncology #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... disorders (e.g. autoimmune ... Chronic myeloid leukemia ... (CML) - Dr. ... Diagnosis #Causes #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... usually IgG) (e.g. lupus ... , CLL, lymphoma, ... differential #diagnosis #hematology ... #anemia
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
EBV infection, Autoimmune ... involved) • No leukemic ... Pylori) - Autoimmune ... Lymphomas • Other hematologic ... #differential #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
cytopenias (usually anemia ... transformation to acute leukemia ... Allogeneic stem cell ... only curative treatment ... #hematology #oncology
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