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diagnosis hematology causes algorithm hemolytic workup agglutinin antibody approach atlas autoimmune bandemia bloodcell bloodsmear borrelia cbc classification clinical cold disease
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Diagnosis Algorithm Blood ... Decreased RBC ... Infiltration Increased RBC ... Thalassemia • RBC ... Disorder • RBC
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... RBC) Morphology ... disease, McLeod blood ... #Morphology #differential ... diagnosis #hematology #microscopy
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Volume (MCV) - Differential ... Algorithm Normal Blood ... Smear • Drugs ... Neutrophils - Low RBC ... RBCs in Rouleaux
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
2) External (RBC ... 3) Internal (RBC ... Defects: Sickle cell anemia ... - Peripheral Blood ... Smear ↑ abnormal
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Autoimmune Hemolytic Anemia ... DIAGNOSE AIHA • Anemia ... ↑ LDH • Anti-RBC ... type ± C3d • Blood ... smear: Differential
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
on the left Myeloblast ... Even with normal WBC ... relative to both WBC ... bacteremia • Abnormal WBC ... 21% had normal WBC
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
decreased PLT count: CBC ... plateletcount), peripheral blood ... smear, HIV/HCV ... changes), high MCV anemia ... disease), HBsAg/anti-HBc
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Immunoglobulin M (IgM) • Blood ... smear - RBC agglutination ... younger pts) Differential ... sensitize red blood ... cells (RBCs) at
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
of Peripheral blood ... smear - Shows schistocytes ... , nucleated RBCs ... from ischemia WBC ... count and differential
Borrelia recurrentis on Peripheral Blood Smear 23M Somali refugee recently arrived w/severe abd pain, confusion and fever
on Peripheral Blood ... Smear 23M Somali ... Hgb 12.5, WBC 14 ... recurrentis #BloodSmear #microscopy ... #pathology #clinical
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