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diagnosis algorithm oncology disease disorders hemolytic rheumatology abnormal agglutinin arthritis atlas bloodcell causes cell chronic classification cold enzymes erythematosus gap
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... Burr Cell RBC (Echinocyte ... Bite Cell RBC: G6PD ... #Morphology #differential ... #diagnosis #hematology
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Blood Disorders ... Pelger-Huet, Macrocytic anemia ... (CLL) - CD38(new ... bcr-able (+) ↑ WBC ... #Disorders #hematology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Bandemia Overview ... Even with normal WBC ... relative to both WBC ... diagnosis #neutrophil #WBC ... #CBC #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
2) External (RBC ... 3) Internal (RBC ... anemia, Thalassemias ... - Peripheral Blood ... #Diagnosis #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
decreased PLT count: CBC ... smear, HIV/HCV testing ... changes), high MCV anemia ... disease), HBsAg/anti-HBc ... #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... Lymphocytosis on CBC ... Lymphocytosis: Absolute blood ... • Neutropenia, anemia ... #oncology #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... hypertension • Unusual RBC ... acanthocytes - Consider RBC ... ARUPLabs #Hemolytic #Anemia ... #hematology #testing
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... • hemolytic anemia ... smear - RBC agglutination ... disease #hemolytic #anemia ... #hematology #diagnosis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Weight loss • Anemia ... Immune hemolytic anemia ... Workup: • Full ... platelets - WBC ... classification #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... result in severe anemia ... immune hemolytic anemia ... from ischemia WBC ... #Hematology
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