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diagnosis differential algorithm causes nephritis renal urine workup classification diseases glomerulonephritis hematuria nephritic syndrome acute blood casts comparison lupus management
Nephritic vs Nephrotic Syndrome Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes. Step
Nephritic vs Nephrotic ... hematuria and/or proteinuria ... the patient have glomerular ... hematuria (RBC ... Comparison #Algorithm #Nephrology
Glomerular Diseases - Nephritic and Nephrotic Syndromes Nephritic syndrome—due to GBM disruption. Hypertension. t BUN and creatinine.
Glomerular Diseases ... RBC casts in urine ... Proteinuria often ... diabetes)) #Glomerular ... #Nephrology #Diagnosis
Glomerular Diseases - Spectrum - Insidious vs Acute - Nephritic (hypertension, hematuria, renal failure) vs Nephrotic
Glomerular Diseases ... Insidious vs Acute - Nephritic ... renal failure) vs Nephrotic ... (Heavy proteinuria ... differential #diagnosis #nephrology
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
• Drugs Glomerular ... urine sediment - WBC ... /RBC casts ... polyangiitis (GPA) / microscopic ... #Nephrology #Differential
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
cells on urine microscopy ... Dysmorphic RBCs and/or RBC ... • Hereditary nephritis ... and >3.5g/day (nephrotic ... range) proteinuria
Algorithmic Approach to Acute Interstitial Nephritis When to suspect AIN? (not sensitive) • AKI, AKD, rapidly progressive
Acute Interstitial Nephritis ... sterile pyuria, WBC ... eosinophiluria, microscopic ... , mild tubular proteinuria ... AIN #Algorithm #nephrology
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
abnormalities of selected glomerular ... EM) Haematuria/nephritis ... Haemolytic-uraemic syndrome Nephrotic ... polyangiitis #glomerular ... #diseases #nephrology
Lupus Nephritis - Diagnostic approach to kidney disease associated with systemic lupus erythematosus (SLE) SLE patient develops
Lupus Nephritis ... develops new: • Proteinuria ... casts, WBC casts ... with evidence of proteinuria ... algorithm #sle #nephrology
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
urine sediment Microscopic ... or dipstick) Glomerular ... • Causes of Glomerular ... Brown urine - Proteinuria ... causes #urology #nephrology
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
evaluated for glomerular ... monitoring low-level glomerular ... disorders #glomerular ... glomerulonephritis #nephrotic ... #nephritic #nephrology
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