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algorithm management approach hemolysis hemolytic leukemia sle vasculitis aortitis arteritis cell comparison diffuse disease disorders druginduced erythematosus extravascular gap giantcell
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
breakdown • Anaemia ... Hemolysis #Hemolytic #Anemia ... #Algorithm #Differential ... #Causes #Workup ... #Hematology #Diagnosis
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Poisoning • Anemia ... Marrow Failure • Anemia ... Myelodysplasia #Anemia ... #Causes #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... Deficiency • Aplastic Anemia ... • Anemia of Chronic ... Non-lmmune #Anemia ... #Causes #Hematology
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Aortitis - Differential ... Diagnosis Framework ... Arteritis (GCA) ... (RA), Systemic lupus ... #Diagnosis #rheumatology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
• Systemic Lupus ... • Rheumatoid Arthritis ... Age > 50 • Chronic ... #Causes #Hematology ... #Oncology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
- Differential ... malignancies • Anemia ... myeloid leukemia (CML ... #Diagnosis #Causes ... #hematology #secondary
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... Neutrophils • Immature/Myeloblasts ... - infiltrates (anemia ... #Leukemia #Hematology ... #Oncology #Diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... usually IgG) (e.g. lupus ... #differential # ... diagnosis #hematology ... #anemia
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Diagnosis: • ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... changes), high MCV anemia ... not required in all ... #Diagnosis #Causes ... #Workup #hematology
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