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differential anemia classification hemolytic activation bruising cryoglobulinemia cryoglobulins extravascular hemolysis intravascular joint leukemia macrophage management mas nonpalpable oncology pain palpable
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Diagnosis Framework ... : - Thrombocytopenia ... PURPURA: Vasculitis ... #hematology #rheumatology ... #nonpalpable #dermatology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Antiphospholipid-antibody syndrome ... lesions • Discoid lupus ... #dermatology ... #differential #diagnosis ... #rheumatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Autoimmune • ITP • SLE ... HUS • DIC • Vasculitis ... #Algorithm #Causes ... #Hematology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... ) - SLE ( ... systemic lupus erythematosus ... infections - Vasculitis ... pediatrics #diagnosis
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Butterfly rash, Vasculitis ... , Purpura, Urticaria ... #Lupus #SLE #systemic ... #erythematosus ... #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... microangiopathy: Thrombotic thrombocytopenic ... purpura (TTP), ... usually IgG) (e.g. lupus ... #hematology #anemia
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... (e.g. systemic lupus ... erythematosus ( ... classification #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus ... SLE], AOSD) • Infection ... , and thrombocytopenia ... #Diagnosis #Management ... #Hematology #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... such as systemic lupus ... erythematosus, ... , and SLE) • Urinalysis ... #rheumatology #
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
hemostasis: - Thrombocytopenia ... (lupus, RA, Sjogren's ... deficiency Work ... #Algorithm #Causes ... #dermatology #physicalexam
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