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differential hematology management causes algorithm signs symptoms oncology pathophysiology rheumatology smear syndrome treatment disease workup classification microscopy neurology pathology acidosis
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
Diagnosis Framework ... Chronic myeloid leukemia ... Acute myeloid leukemia ... leukemia Hypersensitivity ... #Differential #Diagnosis
Evaluation of Leukocytosis: The term 'leukocyte' applies to any cells within the myeloblast, monoblast, & lymphoid lineages. Include
cells within the myeloblast ... eosinophils, & basophils ... Leukemoid reaction ... Leukemoid Reaction ... NEUTROPHILS #WCC #BASOPHILS
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Leukemias Overview ... eosinophilia, basophilia ... Neutrophils • Immature/Myeloblasts ... - infiltrates (anemia ... Hematology #Oncology #Diagnosis
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
- Differential Diagnosis ... hepatomegaly • Labs: anemia ... after initial Rx), basophilia ... #Differential #Diagnosis ... hematology #WBC #Leukemoid
Comparison of basophils and mast cells (in bone marrow). #Basophils #MastCells #Pathology #Marrow #Smear #Microscopy #Comparison #Table
Comparison of basophils ... #Basophils #MastCells ... Comparison #Table #Clinical ... #Diagnosis
Here are very large, immature myeloblasts with many nucleoli. A distincitve feature of these blasts is
large, immature myeloblasts ... acute myelogenous leukemia ... #Clinical #Path
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Megaloblastic Anemia ... Autoimmune hemolytic anemia ... , Thalassemia Basophilic ... interpretation #clinical ... #anemia
Common RBC Inclusions and Associations • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia • Heinz
Severe hemolytic anemia ... Sideroblastic anemia ... , Hemolytic anemia ... Hemoglobin H disease • Basophilic ... Inclusions #Bodies #diagnosis
T-LGL leukemia - T-CeIl Large Granular Lymphocytic Leukemia Clinical - Persistent (>6mo) lymphocytosis (2-20k) with proven clonality
T-LGL leukemia - ... Clinical - Persistent ... Neutropenia (85%), anemia ... Same morphologic/clinical ... hemepath #pathology #diagnosis
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... • Symptomatic anemia ... Diagnosis: • Pancytopenia ... to MDS or acute leukemia ... #diagnosis #management
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