37 results
Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
leading to an allergic ... Sensitization" to Allergen ... Initial exposure to allergen ... after clearance of allergen ... #Immunology #pathophysiology
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
Basophilia - Differential ... Diagnosis Framework Basophils ... blood cell count Basophils ... released during an allergic ... Is It A Real Basophilia
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
mediated; exposure to allergen ... development of allergen-specific ... Allergic reaction ... Initial exposure to allergen ... HypersensitivityReaction #Allergy
Eosinophilia - Differential Diagnosis Algorithm
Idiopathic Eosinophilia
Primary Eosinophilia:
 • Primary hypereosinophilic syndrome
 • Eosinophilic Leukemia
 • MPN/MDS
Eosinophilia - Differential ... Primary Eosinophilia ... Secondary Eosinophilia ... histiocytosis • Allergic ... Diagnosis #Algorithm #allergy
Causes of Eosinophilia - Differential Diagnosis
Bugs:
 - Fungus (aspergillosis)
 - Viral (HIV)
 - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... DRESS - AIN - Eosinophilic ... Glucocorticoids Pugs (Allergies ... ): - Allergic ... Rhinitis - Allergic
Allergic Rhinitis: Pathogenesis and clinical findings

1. Allergy Sensitization -> Antigen Exposure -> APC (macrophages, HLA class
Allergic Rhinitis ... Allergy Sensitization ... (neutrophils, eosinophils ... proliferation of eosinophils ... Tissue edema #Allergic
Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and
attributable to eosinophilia ... confirmed tissue eosinophilia ... with blood eosinophilia ... Secondary Causes: - Allergic ... Malignancy - Immunologic
Differential Diagnosis of Pulmonary Eosinophilia
Infection:
 • Helminthic: Loffler syndrome (Ascaris, hookworm, Strongyloides), Tropical pulmonary eosinophilia (lymphatic
Diagnosis of Pulmonary Eosinophilia ... Tropical pulmonary eosinophilia ... coccidioidomycosis), Allergic ... sting Others: • Eosinophilic ... chronic pulmonary eosinophilia
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... Peripheral blood eosinophilia ... specific symptoms • Eosinophilia ... secondary causes of eosinophilia ... causes are asthma, allergy
Approach to Eosinophilic Lung Diseases
 • Acute Eosinophilic Pneumonia (< 1 wk) - ~30yo, M; Recent
Approach to Eosinophilic ... Diseases • Acute Eosinophilic ... SOB • Chronic Eosinophilic ... ; Hx of asthma/allergies ... loss, malaise • Allergic