13 results
Anaphylaxis: Pathogenesis
Anaphylaxis is a Type 1 hypersensitivity reaction
While the primary mechanism of anaphylaxis is mast cell
cell activation, basophils ... pathophysiology #immunology
Inflammatory mechanism of asthma. 
Airway epithelial cells exposed to activation stimuli, including allergens, viruses, and irritants,
mast cells, and basophils ... mast cells and basophils ... #inflammatory #immunology
Endocarditis - Duke Criteria - Major and Minor

MAJOR CRITERIA: 
 - Persistently +ve blood culture for
Endocarditis - Duke Criteria ... Minor MAJOR CRITERIA ... infection MINOR CRITERIA ... hemorhages - Immunologic ... meet specific criteria
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus
Clinical and Immunologic Criteria

CLINICAL CRITERIA
 - ACUTE CUTANEOUS LUPUS
SLE Diagnostic Criteria ... Erythematosus Clinical and Immunologic ... Criteria CLINICAL ... CRITERIA - ACUTE ... <100,000/MM3) IMMUNOLOGIC
Duke's Criteria for Infective Endocarditis
Definite IE - Pathologic Criteria:
 • Pathologic lesions - vegetation or intracardiac
Duke's Criteria ... IE - Pathologic Criteria ... IE - Clinical Criteria ... Major Criteria: ... Vascular phenomena • Immunologic
Evaluation of Leukocytosis:
The term 'leukocyte' applies to any cells within the myeloblast, monoblast, & lymphoid lineages.
Include
cells within the myeloblast ... eosinophils, & basophils ... NEUTROPHILS #WCC #BASOPHILS
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
Classification Criteria ... lupus nephritis Immunologic ... Classification #Criteria
The algorithm below shows how pre-test probability could be combined with various criteria to determine which
combined with various criteria ... negative Reller Criteria ... negative Bouza Criteria ... chemistries and immunologic
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
eosinophilia, basophilia ... Neutrophils • Immature/Myeloblasts
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
• Petechiae Immunologic ... -> TEE • Duke Criteria