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differential types allergic causes definitions algorithm basophilia basophils dermatology hemolytic nonpalpable palpable pathophysiology platelets purpura rheumatology table thrombocytosis
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Autoimmune Hemolytic anemia ... Dermatitis (ie. reaction ... #Reactions #Types ... #Classification ... #Diagnosis #Definitions
Types of hypersensitivity reactions Type I - lgE-Mediated, Within I Hour (Anaphylaxis) Type II - IgG or IgM
Types of hypersensitivity ... reactions Type ... Days (Hemolytic Anemia ... #Classification ... #Allergy #Diagnosis
Hypersensitivity: Definitions • Type I - Production of lgE Abs that bind to harmless allergens and
Hypersensitivity ... An allergic reaction ... #Hypersensitivity ... #Classification ... #Diagnosis #Definitions
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... hemolysis, deficiency anemia ... post-splenectomy, Exercise, Allergic ... reactions Matthew ... #Differential #Diagnosis
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
- Differential Diagnosis ... released during an allergic ... reaction or asthma ... basophilic leukemia Hypersensitivity ... #causes #hematology
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Hypersensitivity ... When the specific allergen ... sclerosis #Hypersensitivity ... #Types #Classification ... #Diagnosis #Reactions
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... • Transfusion reactions ... #causes #classification ... #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... - Hemolytic anemia ... Vasculitis: • Hypersensitivity ... fever • Drug reactions ... #Differential #Diagnosis
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