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Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... - Differential Diagnosis ... Abnormal peripheral smear ... Anemias (AIHAs) ... #Diagnosis #Algorithm
Dacrocytes (tear drop cells) 
Other poikilocytes resemble a pear or teardrop. The narrow, tapered end
may be
metaplasia, pernicious anemia ... thalassemia, and some hemolytic ... anemias. ... Clinical #Path #BloodSmear ... #Blood #Smear #
Laboratory Testing in Hemolytic Anemia

Intravascular vs Extravascular Hemolysis
Reticulocytes
Unconjugated bilirubin
LDH
Peripheral smear
Haptoglobin
Urine hemosiderin
Urine hemoglobin
Carboxyhemoglobin

#Hemolytic #Anemia #Laboratory #Testing #workup
Anemia Intravascular ... Extravascular Hemolysis ... LDH Peripheral smear ... #Anemia #Laboratory ... Testing #workup #diagnosis
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... - Differential Diagnosis ... • Peripheral blood ... smear + DAT + further ... Recent travel/Fevers
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Anemia 1) DIAGNOSE ... AIHA • Anemia ... type ± C3d • Blood ... smear: Differential ... #Anemia #diagnosis
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Peripheral Blood ... Smear Analysis ... Microangiopathic hemolytic ... #Peripheral #Blood ... #Smear #Analysis
Elliptocyte - 
Note the shape of these appropriately named erythrocytes.
In addition to hereditary elliptocytosis, elliptocytes can
megaloblastic anemia ... myelophthisic anemia ... sideroblastic anemia ... Clinical #Path #BloodSmear ... #Blood #Smear #
Here are very large, immature myeloblasts with many nucleoli. A distincitve feature of these blasts is
large, immature myeloblasts ... Clinical #Path #BloodSmear ... #Blood #Smear #
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
Peripheral blood ... anemia. ... and laboratory diagnosis ... arrow) Peripheral smear ... #Pathology #Smear
Codocytes (Target cells) - Two target cells are seen in the left photo and one in
associated with hemolytic ... anemias, especially ... Clinical #Path #BloodSmear ... #Blood #Smear #