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algorithm causes anemia hemolysis liver extravascular intravascular transaminitis workup agglutinin chemistry cholangitis disease disorders elevated enzymes hepatitis injury interpretation liverenzymes
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Diagnosis Algorithm ... Reticulocytosis • Primary ... Polychromatic Macrocytes, RBC ... Spherocytes, RBC ... #Causes #Hematology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Tests - Differential ... Ducts - PBC ... - CBD stone, Biliary ... Burak @kwburak #LFTs ... #hepatology #LiverFunctionTests
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... Cirrhosis (PBC) ... bile ducts Differential ... #Biliary #Cirrhosis ... #hepatology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... Diagnosis Algorithm ... Drug-induced AIHA - Abnormal ... elliptocytosis - RBC ... #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... usually IgM) (e.g. primary ... • Intrinsic RBC ... Extravascular #Causes #differential ... #diagnosis #hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Autoimmune hepatitis, PBC ... stone, Malignancy, PBC ... function may be abnormal ... hepatitis: < 1 • Cirrhosis ... #hepatology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... 2) External (RBC ... Autoimmune: Warm AIHA, Cold ... 3) Internal (RBC ... Diagnosis #hematology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Bile Ducts • PSC ... Infiltrative • Cirrhosis ... Duct Stone • Biliary ... • Others #LFTs ... #Hepatology #LiverEnzymes
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
15% of AIHA Primary ... Diagnosis: • hemolytic ... Blood smear - RBC ... younger pts) Differential ... #anemia #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
decreased PLT count: CBC ... gastric bypass), LFT ... disease), HBsAg/anti-HBc ... unclear, or if a primary ... #Workup #hematology
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