31 results
Algorithm for the Evaluation and Management of Sickle Cell Crises
Clinical Manifestations and Management

#Diagnosis #Management #Hematology #SickleCell
Evaluation and Management ... of Sickle Cell Crises ... #Diagnosis #Management ... #Hematology #SickleCell ... Manifestations #Workup
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Warm Antibody Autoimmune ... ↑ LDH • Anti-RBC ... 2) LOOK FOR a cause ... Anemia #diagnosis #management ... #treatment #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... decreased PLT count: CBC ... disease), HBsAg/anti-HBc ... or if a primary hematologic ... #Workup #hematology
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
on the left Myeloblast ... Corticosteroid use • Autoimmune ... Even with normal WBC ... 21% had normal WBC ... #CBC #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
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Causes of Extravascular ... Cold AIHA • Alloimmune ... elliptocytosis - RBC ... Diagnosis #Algorithm #Causes ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... idiopathic) - Autoimmune ... • Intrinsic RBC ... Extravascular #Causes ... differential #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
hypertension • Unusual RBC ... acanthocytes - Consider RBC ... elliptocytosis, autoimmune ... Diagnosis #Algorithm #workup ... #hematology #testing
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
Multi-system autoimmune ... pericarditis • Hepatic: PBC ... Scleroderma #SSc #rheumatology ... symptoms #testing #workup
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Diagnosis and Management ... • Immunologic Workup ... Positive in 60-80% of cases ... Usual therapeutic management ... #Summary #rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
, erythema and WBC ... effusion with few WBCs ... weeks) Can Be Caused ... Rheumatologic Disease ... Diagnosis #MSK #rheumatology