16 results
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Warm Antibody Autoimmune ... ↑ LDH • Anti-RBC ... • Blood smear: Differential ... 2) LOOK FOR a cause ... → Systematic screening
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Causes of Extravascular ... Hemolysis - Differential ... Diagnosis Algorithm ... elliptocytosis - RBC ... #Causes #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Causes of Anemia ... Neutrophils - Low RBC ... Cells, Normal WBCs ... • Rule out B12 and ... #Causes #Hematology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Vascular Causes ... stone, Malignancy, PBC ... • Bilirubin: RBC ... cardiac muscle, RBC ... • LDH: Heart, RBC
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
Diagnosis Algorithm ... - Systemic and ... Primary Causes ... Hyperthyroidism CBC ... #causes
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential ... decreased PLT count: CBC ... smear, HIV/HCV testing ... function test, ANA ... disease), HBsAg/anti-HBc
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Antinuclear Antibody ... Testing - Nuclear ... : - PBC, SSc ... , PBC/SSc OS, PBC ... Cytoplasmic #Patterns #differential
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
intralobular bile ducts causes ... cholestasis → Cirrhosis/Liver ... patients • +ANA ... or higher • Liver ... bile ducts Differential
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Diagnosis Algorithm ... Intestine - Other causes ... Pruritis History and ... biliary Cholangitis (PBC ... #hepatology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm

Blood Glucose:
 • Diabetes Mellitus
Liver Function Tests/Enzymes:
Diagnosis Algorithm ... Hyperthyroidism CBC ... Pruritus #secondary #systemic ... #generalized #dermatology ... #causes