32 results
hematology differential algorithm causes hemolytic leukemia chronic hemolysis lymphocytic mds monoclonal myelodysplastic pulmonary syndromes testing thrombocytosis abscess activation acute agglutinin
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
weeks without infection ... Lymphocytosis on CBC ... cells can indicate disease ... • Neutropenia, anemia ... #workup #oncology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Bandemia Overview ... on the left Myeloblast ... • Autoimmune diseases ... Degree of bandemia ... #CBC #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
cytopenias (usually anemia ... risk-stratification • Risks: infection ... Allogeneic stem cell ... #Management #treatment ... #hematology #oncology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Microangiopathic hemolytic anemia ... ) (e.g. lupus, CLL ... • Intrinsic RBC ... #hematology #anemia
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Vmphocytosis on routine CBC ... 5) Symptoms of anemia ... Complications: 1) Infection ... marrow failure with anemia ... #diagnosis #management
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... Neutrophils • Immature/Myeloblasts ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Oncology #Diagnosis
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Artifact (redo CBC ... Myelofibrosis Infectious ... disorders • Celiac disease ... effect following treatment ... Iron deficiency anemia
Multiple Myeloma Diagnosis and Management Summary Clinical Signs: • hyperCalcemia 28% (bone demineralization) • Renal disease 48%
demineralization) • Renal disease ... hypercalcemia) • Anemia ... plus one of: • Anemia ... is also >100 CMC ... #Management #oncology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell ... inclusions - If infection ... ARUPLabs #Hemolytic #Anemia ... #Algorithm #workup
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Cr >2 mg/dL or CC ... 40 ml/min A - Anemia ... diseases, CML, ... plasmacytoma, POEMs syndrome ... #hematology #oncology
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