25 results
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
and Nephrotic Syndromes ... RBC casts in urine ... but in severe cases ... #Nephrotic #Syndromes ... #Proteinuria #Nephrology
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
/nephritic syndromes ... hematuria (RBC casts ... #Syndrome #Comparison ... #Algorithm #Nephrology ... #Diagnosis
Differentiation Between Nephrotic Syndrome and Nephritic Syndrome 
== Nephrotic Syndrome ==
Onset - Insidious 
Edema - ++++
Blood
Red blood cell casts ... Red blood cell casts ... edgarvlermamd - Nephrology ... #Comparison #Table ... #Nephrology #Diagnosis
Urinary Casts and Disease Associations
Hyaline - May be nonspecific; seen in normal individuals or during severe
Urinary Casts and ... breakdown of cellular casts ... heme-granular casts ... edgarvlermamd - Nephrology ... #Diagnosis #Nephrology
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... • Fanconi's syndrome ... sediment - WBC/RBC casts ... polyangiitis (GPA) / microscopic ... #Nephrology #Differential
Atlas of Urine Microscopy Findings
 • Epithelial cells - Normal
 • Renal tubular cells - Acute
Atlas of Urine Microscopy ... • Red cell casts ... • White cell casts ... • Hyaline casts ... #nephrology #casts
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
- Differential Diagnosis ... hematuria: - RBC casts ... - Proteinuria ... #causes #urology ... #nephrology #renal
Urine Microscopy - Casts
Acellular Casts
 • Hyaline Casts - Consists of only precipitated Tamm-Horsfell protein without
Urine Microscopy ... suggestive of nephrotic ... #Urine #Microscopy ... #nephrology #interpretation ... #diagnosis
Hematuria Workup and Diagnosis Algorithm
 • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
, RBC casts, dysmorphic ... → Refer to Nephrology ... for renal biopsy ... cystoscopy • Refer to Nephrology ... if cause not identified
Albuminuria (Grades) and Risk for CKD
Normal to mildly increased albuminuria:
 - Albumin excretion rate: < 30
associated with worse renal ... Urine total protein ... syndrome ... #CKD #nephrology ... #diagnosis #proteinuria