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differential hematology oncology management algorithm chronic classification hiv hodgkins neurology rheumatology abdominal acute aids anemia apl aplastic auerrods barre blood
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... • Immature/Myeloblasts ... Age: 50-60 • Auer ... • Tumor lysis syndrome ... #Oncology #Diagnosis
A 37-year-old woman initially presented with pancytopenia and found to have leukopenia (2.1 × 103/μL) with
She was diagnosed ... promyelocytic leukemia ... a bone marrow (BM ... hospitalization and treatment ... acute myeloid leukemia
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 Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Lymphadenopathy ... - Differential Diagnosis ... Infectious • EBV ... #Algorithm #Causes
Hyperviscosity Syndrome - Causes and Treatment - Waldenstrom macroglobulinemia (most common) / Plasmapheresis - Multiple
Hyperviscosity Syndrome ... - Causes and Treatment ... hyperleukocytosis (AML ... - MH/CCF/CWRU EM ... #Diagnosis #Treatment
Differential Diagnosis for Generalized Lymphadenopathy Viral • HIV • EBV • CMV • HBV • Dengue • Rubella
Differential Diagnosis ... Viral • HIV • EBV ... Malignancy • Lymphoma ... • Leukemia • ... #Causes #Algorithm
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
phenomenon CLL Diagnosis ... microglobulin Treatment ... • Richter’s Syndrome ... • Sezary syndrome ... #diagnosis #workup
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- Differential Diagnosis ... (NHL) ~60% - lymphadenopathy ... Responsive to Treatment ... Treated Like Acute Leukemias ... relapse - Amy
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Immunosuppression (e.g., HIV), EBV ... involved) • No leukemic ... disease: B symptoms, lymphadenopathy ... Differential Diagnosis ... comparison #oncology #diagnosis
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... - Differential Diagnosis ... Primary: - CML ... - Lymphomas ... Hypereosinophilic Syndrome
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
- Differential Diagnosis ... Lemierre's syndrome ... Brucellosis, Q fever, EBV ... malignancies: Lymphoma ... , Leukemia, Multiple
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