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Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... on the left Myeloblast ... Tissue damage • Leukemia ... likelihood of negative clinical ... #Bandemia #differential
Here are very large, immature myeloblasts with many nucleoli. A distincitve feature of these blasts is
large, immature myeloblasts ... acute myelogenous leukemia ... #Clinical #Path
Evaluation of Leukocytosis: The term 'leukocyte' applies to any cells within the myeloblast, monoblast, & lymphoid lineages. Include
cells within the myeloblast ... Leukemoid reaction ... part automated differential ... Leukemoid Reaction ... D/D leukemia: increases
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Leukemias Overview ... , CLL Acute leukemias ... Chronic leukemia ... Lymphoblastic Leukemia ... Neutrophils • Immature/Myeloblasts
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Lymphadenopathy - Differential ... Neoplastic: - Leukemia ... Lymphoblastic Leukemia ... Pancytopenia, WBC differential ... Lymphadenopathy #LAD #Differential
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm Infection • Bacterial • Abscess • Viral Medications
Neutrophils - Differential ... Chronic myelogenous leukemia ... Polycythemia vera Acute Leukemia ... #Neutrophils #Differential
Causes of Diffuse and Localized Lymphadenopathy - Differential Diagnosis Algorithm • Reactive (Inflammatory / Infectious) •
Lymphadenopathy - Differential ... • Neoplastic (Leukemia ... Lymphadenopathy #LAD #Differential
T-LGL leukemia - T-CeIl Large Granular Lymphocytic Leukemia Clinical - Persistent (>6mo) lymphocytosis (2-20k) with proven clonality
T-LGL leukemia - ... Granular Lymphocytic Leukemia ... Clinical - Persistent ... Predominantly leukemic ... Same morphologic/clinical
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
Hyperuricemia - Differential ... Lymphoblastic Leukemia ... Acute Myeloid Leukemia ... Chronic Myeloid Leukemia ... Hyperuricemia #Differential
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
Basophilia - Differential ... Chronic myeloid leukemia ... Acute myeloid leukemia ... Acute basophilic leukemia ... #Basophilia #Differential
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