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aflp blood coagulation liver obstetrics pathophysiology pregnancy reactions abnormal algorithm anemia aptt arterial bleeding bruising disease disseminated embolism extravascular fatty
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... coagulation (DIC ... microangiopathy: Thrombotic thrombocytopenic ... #Causes #differential ... #diagnosis #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... - Differential ... Leukemia, Tumour ... • TTP/HUS • DIC ... #Causes #Hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... promyelocytic leukemia ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Neutrophils • Immature/Myeloblasts ... infiltrates (anemia, thrombocytopenia ... Fibrinolysis & DIC ... #Hematology #Oncology ... #Diagnosis
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
features: Hemolysis, Thrombocytopenia ... DIC • Aminotransferases ... Disease #Pregnancy #hepatology ... #differential # ... diagnosis #icp #
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Disseminated intravascular ... coagulation (DIC ... #diagnosis #differential ... #hematology #coagulation
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Diagnosis Framework ... Hyperhomocysteinemia - Heparin-induced ... thrombocytopenia ... - Disseminated intravascular ... pathophysiology #hematology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
acid metabolism products ... = nonspecific (nausea ... rapidly develops (DIC ... infiltration) Differential ... Liver #Pregnancy #hepatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
for Thrombotic Thrombocytopenic ... Fibrin degradation products ... reflection of intravascular ... WBC count and differential ... #Workup #Hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
gingivitis or gingival leukemic ... Acquired: • Heparin ... , disseminated intravascular ... discern these causes ... #Diagnosis #Hematology
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