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differential aptt bruising oncology prolonged pt arterial bleeding dic embolism hemostasis intravascular mds myelodysplasia myelodysplastic pathophysiology pediatrics peds purpura syndromes
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
dysfunction (25%) • Hepatic ... deficiency) • HIT: Heparin-PF4 ... 100mg/dL) - Heparin ... #diagnosis #causes ... #hematology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
- DIC (disseminated ... intravascular coagulation ... Acquired - Aplastic ... infiltration (e.g. leukaemia ... peds #pediatrics #diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... in aplastic anemia ... #hematology #diagnosis ... #management
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
(e.g. heparin contamination ... thrombin inhibitors, heparin ... hemorrhage • Disseminated ... amyloidosis #Abnormal ... #hematology #coagulation
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... unfractionated heparin ... e.g. heparin ... thrombin inhibitors, heparin ... #hematology #coagulation
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Hyperhomocysteinemia - Heparin-induced ... thrombocytopenia ... - Disseminated ... and other causes ... pathophysiology #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
gingivitis or gingival leukemic ... Acquired: • Heparin ... liver failure, disseminated ... discern these causes ... #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
• Anemia • Aplastic ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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