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differential management anemia blood extravascular hemolytic bleeding bruising coagulation dic disseminated hemostasis mds myelodysplasia myelodysplastic nonpalpable oncology palpable petechiae petechial
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... usually IgG) (e.g. lupus ... G6PD deficiency) ... #Hemolytic #Intravascular ... #diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Diagnosis Algorithm ... • MAHA (TTP ... #Algorithm #Causes ... #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... blood loss, Acute hemolysis ... , deficiency anemia ... #Algorithm #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Algorithm • Sickle ... with or without platelet ... thrombocytopenia - DIC, TTP ... #Algorithm #workup ... #hematology #testing
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
/HUS - Hemolytic ... necrosis) • VIT K deficiency ... fever • Drug reactions ... #hematology #rheumatology ... #nonpalpable #dermatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... Fibrin degradation products ... reflection of intravascular ... hemolysis Platelet ... #Workup #Hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Crossmatch - involves testing ... recipients w/ IgA deficiency ... false negatives on testing ... #Transfusions #diagnosis ... #management #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
recipients w/ IgA deficiency ... Transfusion Purpura (PTP ... false negatives on testing ... #Transfusion #diagnosis ... #management #hematology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
fulminans - DIC - TTP ... Autoimmune Vasculitis (lupus ... Work Up: • ... #Algorithm #Causes ... #dermatology #physicalexam
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... promyelocytic leukemia ... thrombopoietin deficiency ... #Coagulation #diagnosis ... #management #hematology
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