26 results
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
- Differential Diagnosis ... Reactive: • Anemia ... deficiency) • Infection ... Chronic Myeloid Leukemia ... causes #Platelets #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
and Management ... cytopenias (usually anemia ... risk-stratification • Risks: infection ... transformation to acute leukemia ... #hematology #oncology
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
: • Recurrent infections ... Diagnosis: • Pancytopenia ... to MDS or acute leukemia ... #diagnosis #management ... #treatment #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
pain, bleeding, infections ... Neutrophils • Immature/Myeloblasts ... - infiltrates (anemia ... #Hematology #Oncology ... #Diagnosis
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
- Differential Diagnosis ... Megakaryopoiesis • Aplastic Anemia ... Leukemia, Tumour ... Vasculitis • Infection ... Algorithm #Causes #Hematology
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
on the left Myeloblast ... Differential Diagnosis ... Tissue damage • Leukemia ... #differential #diagnosis ... neutrophil #WBC #CBC #hematology
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
- Differential Diagnosis ... deficiency • Fanconi’s anemia ... Cancer: • Leukemia ... deficiency Infections ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
- Differential Diagnosis ... Thrombocytosis): • Acute infection ... malignancies • Anemia ... Chronic myeloid leukemia ... #Causes #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
adults in the west ... weeks without infection ... • Neutropenia, anemia ... #diagnosis #workup ... #oncology #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
minimal tumor burden Diagnosis ... Complications: 1) Infection ... #oncology #hematology ... #hemeonc #diagnosis ... #management